UK Study Warns Against Anti-Psychotics for Dementia
More than 140,000 dementia patients in Britain are given anti-psychotic drugs needlessly and overprescribing of the medicines is linked to an extra 1,800 deaths in elderly Britains each year, a British government-backed review said.
The report makes several recommendations, mainly that people with dementia should receive antipsychotics only when they really need them, and that reducing their use in this group should be a priority for Britain’s National Health Service (NHS). It suggests this can be achieved by various means including training carers and medical staff to use alternatives to antipsychotics, providing psychological therapies for people with dementia and their carers, carrying out further research into alternative treatments, and audits.
Anti-psychotic drugs include generic treatments like thioridazine, chlorpromazine, haloperidol, trifluorperazine and Johnson & Johnson's Risperdal, Eli Lilly and Co's Zyprexa, and Seroquel, made by AstraZeneca, which are among the top-selling drugs worldwide.
Antipsychotics prescription is necessary in certain circumstances. In line with Britain’s National Institute of Health and Clinical Excellence (NICE)guidance, the drugs should only be used when a person is a risk to themselves or others, and where all other methods have been tried. This should be for a short period of three months only, while a care plan is put in place.
Why are antipsychotics used in dementia?
Antipsychotics are used to manage the psychological and behavioural symptoms of dementia. These include aggression, agitation, shouting and sleep disturbance. It is important to find ways to deal with these symptoms as they can cause major problems for the person with dementia and their carers.
What did the report find?
The report found that the current approach to treating the psychological and behavioural symptoms of dementia appears to be largely based on the use of antipsychotics. It also found that the evidence regarding the use of antipsychotics in people with dementia is complex, sometimes contradictory and contains gaps. Due to the gaps in the evidence, any conclusions need to be drawn cautiously.
The report concluded that, overall, the evidence suggests that antipsychotics appear to have only a limited positive effect in treating these symptoms and cause significant harm to people with dementia.
However, it also said that some people with dementia do benefit from antipsychotics and there are likely to be specific subgroups of people with dementia who benefit, such as those with severe symptoms. It said this has not yet been tested in rigorous trials.
Based on the best evidence available, Professor Banerjee estimated that:
- Each year, 180,000 people with dementia receive antipsychotics in England.
- Up to 36,000 of these people benefit to some degree from the treatment.
- Around 1,620 additional cerebrovascular adverse events (such as stroke) will result from the treatment. About half of these will be severe.
- Each year, about 1,800 additional deaths will be caused by the treatment in this frail population.
What recommendations does the review make?
The report makes 11 recommendations that aim to reduce the use of antipsychotics to a level where the benefits outweigh the risks. Professor Banerjee estimated that antipsychotic use could be reduced to a third of its current level, and that this could be done safely over 36 months.
Broadly, the report recommends that:
- People with dementia should receive antipsychotics only when they really need them.
- Reducing the use of antipsychotics in people with dementia should be a priority for the NHS.
- Care home staff are given a curriculum to develop skills in non-pharmacological treatment of behavioural disorder in dementia.
- Care homes could be assessed based on their use of antipsychotic medications and the availability of staff who are skilled in non-pharmacological management of behavioural and psychological symptoms in dementia.
- Psychological therapy resources should be made available for people with dementia and their carers.
- Further research should be carried out, including studies of non-pharmacological methods of treating behavioural problems in dementia and of alternative pharmacological treatments.
Are there any other important points to note?
This report only looks at the use of antipsychotics in people with dementia. It does not apply to people who are prescribed antipsychotics for other conditions, such as schizophrenia. It is important that people with dementia do not stop taking any prescription medications without first consulting their doctor.
NICE recommendations on the use of antipsychotics in dementia include:
- People with dementia who develop non-cognitive symptoms (psychosis and/or agitated behaviour causing significant distress) or challenging behaviour should be offered a pharmacological treatment in the first instance only if they are severely distressed or there is an immediate risk of harm to the person or others. An assessment to establish likely factors that may cause, aggravate or improve such behaviour should be carried out at the earliest possible opportunity and a care plan drawn up.
- People with Alzheimer’s disease, vascular dementia, mixed dementias or dementia with Lewy Bodies (DLB) with mild-to-moderate non-cognitive symptoms should not be prescribed antipsychotic drugs because of the possible increased risk of cerebrovascular adverse events (e.g. stroke) and death. Those with DLB are at particular risk of severe adverse reactions.
- People with Alzheimer’s disease, vascular dementia, mixed dementias or DLB with severe non-cognitive symptoms may be offered treatment with an antipsychotic drug provided there is a full discussion with the person and their carers of the risks of adverse effects, there are specific treatment aims and goals and treatment effects which are regularly assessed and recorded. The drug should be selected on an individual basis, started at low dose, monitored regularly and changed or withdrawn as indicated.
Links to the science
- The use of antipsychotic medication for people with dementia: Time for action. A report for the Minister of State for Care Services by Professor Sube Banerjee. Department of Health 2009 (PDF)
Further reading
Supporting people with dementia and their carers in health and social care. NICE guideline on dementia: November 2006 (PDF)
-From: “UK Study Warns Against Anti-Psychotics for Dementia” By Kate Kelland, from Reuters Health Information, Medscape Psychiatry News http://www.medscape.com/viewarticle/712262 retrieved 11/3/09 and “ Antipsychotic use in dementia: Behind the Headlines”
Brought to you by the NHS Knowledge Service, November 13 2009 http://www.nhs.uk/news/2009/10October/Pages/Antipsychotic-use-in-dementia.aspx retrieved 11/27/09.
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