The Department of Anesthesia, Critical Care and Pain Medicine
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DAY 01/02 - Friday, June 9: Therapeutic gases & scientific discoveries |
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| Time | Presentation | Video |
| 08:30-09:15 AM | Opening session: "The Warren M. Zapol Symposium on Anesthesia ritical Care Research" Chair: Oluwaseun Johnson-Akeju 1. Oluwaseun Johnson-Akeju and Robert E. Kingston: Welcome & Introduction 2. Nikki, David, Liza Zapol and Paul Alfille: Family reflections *** Short break and restart @ 9:30 AM *** |
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| 09:30-11:00 AM | Nitric oxide Chairs: Lorenzo Berra & Fumito Ichinose 1. Louis Ignarro: Biology of nitric oxide 2. Jesse Roberts: Nitric oxide - a critical regulator of newborn lung developmentand function 3. Mark Gladwin: Nitric oxide, metabolites and hemoglobin *** Short break and restart @ 11:15 AM *** |
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| 11:15-12:15 PM | Sickle cell anemia, carbon monoxide, and hydrogen sulfide Chairs: Mark Gladwin & Donald Bloch 1. Akito Nakagawa: Identification of small molecules that regulate the affinity of hemoglobin for oxygen; implications for the treatment of sickle cell disease 2. Luca Zazzeron: Carbon monoxide poisoning and phototherapy 3. Fumito Ichinose: Hydrogen sulfide - from suspended animation to neuroprotection *** Lunch break *** |
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| 1:45-2:45 PM | A world of discoveries: PART 1 Science from the artic and beyond Chairs: Stuart Harris & James Rathmell 1. Mead Treadwell: Polar Biology, Geophysics, and Human Health: What Explorer and Adventurer Warren Zapol brought home 2. Manu Buys: Following in the footsteps of Warren's Weddell seal research: sight and sounds of Antarctica 3. Jessica Meir: Taking direction from specially adapted animals: experimenting on the ice and amongst the stars (A portion of the video has been removed as it was unpublished.) *** Short break and restart @ 3:00 PM *** |
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| 3:00-4:30 PM | A world of discoveries: PART 2 Evolution, oxygen and wilderness: Learning from mammalian adaptations to extreme conditions Chairs: Emmanuel Buys & Ryan Carroll 1. Paul Falkowski: The emergence of oxygen and the evolution of large placental mammals 2. Vamsi Mootha: Hypoxia as a therapy for mitochondrial disease 3. Diana Laird: Extreme reproductive longevity in the naked mole-rat 4. N. Stuart Harris: Physiological adaptation to extreme conditions *** Short break and restart @ 4:45 PM *** |
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| 4:45-5:30 PM | The Warren M. Zapol Symposium Lecture Introduction by ~ Oluwaseun Johnson-Akeju Emery N. Brown: Anesthesia and the brain: new understanding in neurosciences *** Short break and restart @ 4:45 PM *** |
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DAY 02/02 - Saturday, June 10: Nitric Oxide, Respiratory Failure, Sepsis and Innovation in Medicine |
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| Time | Presentation | Video |
| 08:30-09:30 AM | PART 1: Nitric Oxide Nitric Oxide & Respiratory Failure Chairs: Fumito Ichinose & Louis Ignarro 1. Carl Nathan: Nitric oxide: antimicrobial mechanisms and bacterial resistance 2. Lorenzo Berra: High dose inhaled nitric oxide: recent clinical findings 3. Pankaj Arora: Recent advances in the clinical use of inhaled nitric oxide *** Short break and restart @ 9:45 AM *** |
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| 09:45-11:00 AM | PART 2: Respiratory failure the known and unknown Chairs: Antonio Pesenti & Jeanine Wiener-Kronish 1. Daniel Talmor: What we learned (and did not) during Covid-19 and in ARDS 2. Katerina Vaporidi:: Respiratory drive in respiratory failure 3. Maurizio Cereda: Lung imaging in respiratory failure 4. Ryan Carroll: Respiratory failure in children *** Short break and restart @ 11:15 AM *** |
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| 11:15-12:15 PM | Sepsis, Inflammation, and Atherosclerosis Chairs: Donald Bloch & Maurizio Cereda 1. H. Shaw Warren: Sepsis, and animal models to study sepsis 2. Aranya Bagchi: Iron and inflammation 3. Rajeev Malhotra: Atherosclerosis and vascular calcification mechanisms *** Lunch break *** |
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| 1:15-2:15 PM | Innovation in pain and neuroplasticity Chairs: Jianren Mao & Clifford Woolf 1. Clifford Woolf: Understanding and conquering pain 2. Gary Brenner: Attenuated Salmonella typhimurium as immunotherapy for painful nerve sheath tumors *** Short break and restart @ 2:30 PM *** |
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| 2:30-3:30 PM | Innovation in medicine Chairs: Ryan Carroll, Nathaniel Sims and David Zapol PART 1: How to go about innovation in research, in academia and in education. 1. Richard Rox Anderson: Teaching out of the box: an MIT course on innovation 2. Paul Yu: A journey from basic science lab discovery to drug Development. 3. Robert Langer: From nanotechnology to mRNA therapies, and what's to come: How overcoming skepticism and barriers led to new cancer and heart disease treatments, vaccines, and ways to tackle global health challenges *** Short break and restart @ 3:45 PM *** |
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| 3:45-4:45 PM | Innovation in medicine Chairs: Ryan Carroll, Nathaniel Sims and David Zapol PART 2: Inhaled nitric oxide therapy from idea to commercialization: A thirty-year story. 4. Ashleigh Palmer: Visionary and pragmatist-Lightning only strikes once… 5. Binglan Yu: Beyond cylinders: production of nitric oxide from air 6. David Zapol: Next generation nitric oxide |
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| 4:45-5:00 PM | Fumito Ichinose: Concluding Remarks |
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